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July 1, 2000Nephrology Dialysis TransplantationOpen Access

Increased frequency of angiotensin‐converting enzyme DD genotype in patients with type 2 diabetes in Taiwan

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Why the study?

Is the ACE DD genotype associated with type 2 diabetes and diabetic nephropathy in Taiwanese patients?

Population

599 individuals in Taiwan, comprising 336 patients with type 2 diabetes and 263 age-matched normal controls.

Design

Case-control

Authors

MHMing‐Chia HsiehKaohsiung Medical UniversitySLShiu‐Ru LinNational Academy of MedicineTHTusty‐Jiuan HsiehKaohsiung Medical University

Discussion

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Implication

Supports genetic risk research in East Asian diabetes; hypothesis-generating and should not yet change practice.

Structured PICO

Is the ACE DD genotype associated with type 2 diabetes and diabetic nephropathy in Taiwanese patients?

P
Population
599 individuals in Taiwan, comprising 336 patients with type 2 diabetes (157 without nephropathy and 179 with nephropathy defined as daily protein loss >500 mg) and 263 age-matched normal controls.
O
Outcome
Distribution of ACE-I/D genotypesurrogate

The ACE DD genotype is significantly associated with type 2 diabetes and the severity of diabetic nephropathy in the Taiwanese population.

Cite This Study

Hsieh et al. (2000) studied this question.

synapsesocial.com/papers/6a906dae6bfd95d7bd4de3b6https://doi.org/10.1093/ndt/15.7.1008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin-Converting Enzyme Polymorphism and Development of Diabetic Nephropathy in Non-Insulin-Dependent Diabetes mellitus2008 · 74 citations
  2. 2Angiotensin converting enzyme insertion/deletion polymorphism1994 · 179 citations
  3. 3Angiotensin Converting Enzyme Gene Polymorphism and Its Enzyme Activity in Serum in Young Japanese Females.1997 · 14 citations
  4. 4Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese.1994 · 275 citations
  5. 5Polymorphism of Angiotensin Converting Enzyme Gene Is Associated With Circulating Levels of Plasminogen Activator Inhibitor-11997 · 81 citations