Key result
ACE gene I/D polymorphism distribution did not differ significantly between type 2 diabetic patients and controls, though the ID genotype was associated with diabetic neuropathy.
Why the study?
Is the ACE gene I/D polymorphism associated with diabetic complications in Turkish patients with type 2 diabetes mellitus?
Case-Control (n=276)
Is the ACE gene I/D polymorphism associated with diabetic complications in Turkish patients with type 2 diabetes mellitus?
The ACE gene I/D polymorphism does not differ between Turkish type 2 diabetics and controls, but specific genotypes may influence ACE activity and the risk of diabetic neuropathy and retinopathy.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for ID genotype in diabetic neuropathy; does not support ACE polymorphism screening in Turkish T2DM.
We aimed to investigate the angiotensin-converting enzyme (ACE) gene polymorphism, ACE activity and their associations with diabetic complications in Turkish patients with type 2 diabetes mellitus. A total of 143 patients and 133 controls were screened for ACE gene I/D polymorphism by using polymerase chain reaction. Serum ACE activities were determined spectrophotometrically. There was no significant difference in the distribution of ACE I/D genotypes between patients and controls. The patients with DD genotype had a higher ACE activity than those with ID and II. Hypertensive diabetic patients with DD genotype had higher ACE activities than those with ID and II. There was no significant difference in the distribution of ACE I/D genotypes between patients with and without nephropathy, retinopathy and hypertension except for patients with and without neuropathy. In patients with DD genotype, creatinine clearance correlated with duration of diabetes. The grade of retinopathy was correlated with duration of diabetes in DD and ID genotypes. The highest ACE activity was measured in hypertensive diabetics with DD genotype. ID genotype was suggested to be a risk factor and II was suggested to be protective for diabetic neuropathy. The DD and ID genotypes might be a predictor for the development of retinopathy in relation to duration of diabetes.
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Değirmenci et al. (2005) conducted a case-control in Type 2 diabetes mellitus (n=276). ACE gene I/D polymorphism vs. Controls and different genotypes was evaluated on Distribution of ACE I/D genotypes between patients and controls. ACE gene I/D polymorphism distribution did not differ significantly between type 2 diabetic patients and controls, though the ID genotype was associated with diabetic neuropathy.
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