What question did this study set out to answer?

To examine the association between angiotensin-converting enzyme (ACE) gene polymorphisms and susceptibility to type 2 diabetes and diabetic nephropathy.

August 1, 2004Experimental & Molecular MedicineOpen Access

Angiotensin-I converting enzyme gene polymorphism in Turkish type 2 diabetic patients

View Full Paper

Ask AI

Bookmark

Why the study?

Is ACE gene polymorphism associated with type 2 diabetes or diabetic nephropathy in Turkish patients?

Population

112 Turkish individuals, comprising 75 type 2 diabetic patients and 37 healthy controls.

Comparison

ACE gene polymorphism (DD, ID, II genotypes) vs Healthy controls and diabetic patients without…

Design

Case-control

Authors

AEArzu ErgenIstanbul University HHHüsrev HatemiIstanbul University-Cerrahpaşa BABedia AğaçhanIstanbul University

Discussion

Member takes

Implication

ACE DD genotype may confer type 2 diabetes susceptibility in Turkish adults; leaves open association with diabetic nephropathy.

Key Points

To examine the association between angiotensin-converting enzyme (ACE) gene polymorphisms and susceptibility to type 2 diabetes and diabetic nephropathy.
Enrolled 75 patients with type 2 diabetes (25 with nephropathy, 50 without nephropathy) and 37 healthy control subjects.
Determined ACE gene insertion/deletion (I/D) polymorphisms via polymerase chain reaction (PCR) amplification using allele-specific primers.
Frequencies of ACE DD, ID, and II genotypes were 48%, 42%, and 10% in type 2 diabetic patients compared to 27%, 60%, and 13% in healthy controls, with the DD genotype significantly higher in diabetic patients (P < 0.05).
Type 2 diabetic patients carrying the DD genotype without nephropathy exhibited a 1.77-fold increase compared to healthy controls (P < 0.05).
No statistically significant correlation was identified between ACE gene polymorphism and the development of diabetic nephropathy.

Structured PICO

Is ACE gene polymorphism associated with type 2 diabetes or diabetic nephropathy in Turkish patients?

Population

112 Turkish individuals, comprising 75 type 2 diabetic patients (25 with nephropathy, 50 without nephropathy) and 37 healthy controls.

Intervention

ACE gene polymorphism (DD, ID, II genotypes)

Comparator

Healthy controls and diabetic patients without nephropathy

Outcome

Association of ACE gene polymorphism with type 2 diabetes and diabetic nephropathysurrogate

The ACE DD genotype is associated with an increased risk of type 2 diabetes in a Turkish population, but it does not appear to be correlated with the development of diabetic nephropathy.

Cite This Study

Ergen et al. (2004) studied this question.

synapsesocial.com/papers/6a7d648f2ad457ac687755e2 https://doi.org/10.1038/emm.2004.45

View Full Paper

Ask AI

Bookmark

Angiotensin-I converting enzyme gene polymorphism in Turkish type 2 diabetic patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Angiotensin-I converting enzyme gene polymorphism in Turkish type 2 diabetic patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider