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January 1, 2008Journal of the Renin-Angiotensin-Aldosterone SystemOpen Access

Lack of association between the angiotensin-converting enzyme gene (I/D) polymorphism and diabetic nephropathy in Tunisian type 2 diabetic patients

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Why the study?

Is the ACE (I/D) polymorphism associated with diabetic nephropathy or type 2 diabetes in the Tunisian population?

Population

244 individuals from the Tunisian population, comprising 141 unrelated type 2 diabetic patients and 103…

Comparison

Angiotensin-converting enzyme insertion/deletion… vs Non-diabetic controls and type 2 diabetic…

Design

Case-control

Authors

IAImen ArfaTunis UniversityAAAbdelmajid AbidUniversity of ViennaSNSonia NouiraTunis University

Discussion

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Implication

No association of ACE I/D polymorphism with diabetic nephropathy in Tunisians; leaves open ethnic-specific effects in larger prospective studies.

Structured PICO

Is the ACE (I/D) polymorphism associated with diabetic nephropathy or type 2 diabetes in the Tunisian population?

P
Population
244 individuals from the Tunisian population, comprising 141 unrelated type 2 diabetic patients (90 with nephropathy, 51 without) and 103 non-diabetic controls with normal fasting blood glucose.
I
Intervention
Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism (DD, ID, II genotypes)
C
Comparator
Non-diabetic controls and type 2 diabetic patients without nephropathy
O
Outcome
Association with diabetic nephropathy and type 2 diabetessurrogate

The ACE (I/D) polymorphism does not appear to be associated with diabetic nephropathy or type 2 diabetes in the Tunisian population.

Limitations

  • Preliminary study

Cite This Study

Arfa et al. (2008) studied this question.

synapsesocial.com/papers/6a906dae6bfd95d7bd4de3b3https://doi.org/10.3317/jraas.2008.002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin-Converting Enzyme Genotype in Blacks with Diabetic Nephropathy: Effects on Risk of Diabetes and Its Complications2003 · 9 citations
  2. 2Haplotype structure of five SNPs within the ACE gene in the Tunisian population2006 · 14 citations
  3. 3Prognostic Value of Angiotensin-I Converting Enzyme I/D Polymorphism for Nephropathy in Type 1 Diabetes Mellitus2001 · 120 citations
  4. 4The Angiotensin-Converting Enzyme DD Genotype Is Associated With Glomerulopathy Lesions in Type 2 Diabetes2002 · 44 citations
  5. 5Effect of angiotensin-converting enzyme (ACE) gene polymorphism on progression of renal disease and the influence of ACE inhibition in IDDM patients: findings from the EUCLID Randomized Controlled Trial. EURODIAB Controlled Trial of Lisinopril in IDDM.1998 · 161 citations