Key result
The ACE DD genotype was significantly more frequent in patients with type 2 diabetes compared to healthy controls (P<0.001), indicating increased disease susceptibility.
Why the study?
Is the ACE I/D polymorphism associated with an increased susceptibility to type 2 diabetes in Arab and Berber populations of Jerba Island, Tunisia?
Population
272 individuals from two ethnic groups in Jerba Island, Tunisia.
Comparison
Angiotensin-converting enzyme insertion/deletion… vs Healthy normoglycaemic controls
Design
Case-control
Authors
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May inform T2D risk stratification in Tunisian Arab/Berber groups; leaves open clinical utility pending prospective validation.
Case-Control (n=272)
Is the ACE I/D polymorphism associated with an increased susceptibility to type 2 diabetes in Arab and Berber populations of Jerba Island, Tunisia?
p-value: p=<0.001
The ACE DD genotype is associated with an increased susceptibility to type 2 diabetes in Arab and Berber populations in Tunisia.
Baroudi et al. (2009) conducted a case-control in type 2 diabetes (n=272). ACE I/D polymorphism (DD genotype) vs. Healthy normoglycaemic controls was evaluated on Type 2 diabetes susceptibility (p=<0.001). The ACE DD genotype was significantly more frequent in patients with type 2 diabetes compared to healthy controls (P<0.001), indicating increased disease susceptibility.
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