Key result
The D allele of the ACE gene was significantly more frequent in Malaysian subjects with hypertension (36.9%), T2DM (39.2%), and both (42.3%) compared to controls (22.9%; p<0.05).
Why the study?
Is the insertion/deletion polymorphism of the ACE gene associated with essential hypertension and type 2 diabetes mellitus in Malaysian subjects?
Population
260 Malaysian subjects consisting of 65 with essential hypertension, 60 with type 2 diabetes mellitus, 65…
Comparison
Presence of the deletion allele of the… vs Controls without HTN or T2DM
Design
Case-control
Authors
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May aid Malaysian risk stratification; hypothesis-generating and requires prospective validation before practice change.
Case-Control (n=260)
Is the insertion/deletion polymorphism of the ACE gene associated with essential hypertension and type 2 diabetes mellitus in Malaysian subjects?
p-value: p=< 0.05
The D allele of the ACE gene is significantly associated with essential hypertension and type 2 diabetes mellitus in the Malaysian population.
Ramachandran et al. (2008) conducted a case-control in Essential hypertension and type 2 diabetes mellitus (n=260). Deletion (D) allele of the angiotensin-converting enzyme (ACE) gene vs. Controls was evaluated on Genotype and allele frequency of the ACE gene polymorphism (p=< 0.05). The D allele of the ACE gene was significantly more frequent in Malaysian subjects with hypertension (36.9%), T2DM (39.2%), and both (42.3%) compared to controls (22.9%; p<0.05).
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