Key result
The ACE gene DD genotype and D allele frequencies were significantly higher in elderly hypertensive and diabetic hypertensive patients compared to healthy controls, indicating ACE gene deletion is a risk factor for hypertension but not specifically for diabetes.
Case-Control (n=603)
No
Absolute Event Rate: 35.2% vs 13.3%
p-value: p=<0.001
The ACE gene DD genotype and D allele are associated with an increased risk of hypertension and elevated lipid levels, but not type 2 diabetes, in the Chinese elderly population.
ACE DD genotype associated with hypertension risk but not diabetes in elderly Chinese; hypothesis-generating and should not yet change practice.
OBJECTIVE: To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and diabetic essential hypertension in elderly population. METHODS: Polymerase chain reaction (PCR) technique was used in 260 elderly normal control patients, 205 elderly hypertensive patients and 138 elderly diabetic hypertensive patients to detect the I/D polymorphism in ACE gene. RESULTS: DD genotype frequency (0.352) and D allele frequency (0.543) in elderly hypertensive patients were higher than those in the normal control patients. DD genotype (0.421) and D allele frequency (0.579) in elderly diabetic hypertensive patients were significantly higher than those in the control patients (0.133 and 0.250). The differences of DD genotype and D allele frequency between the elderly hypertensive patients and the elderly diabetic hypertensive patients were not significant (P > 0.05). CONCLUSION: ACE gene deletion is a risk factor for hypertension but is not a risk factor for diabetes in elderly population.
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Zhou et al. (2013) conducted a case-control in Elderly diabetic hypertension and essential hypertension (n=603). ACE gene insertion/deletion (I/D) polymorphism (DD genotype) vs. Healthy controls was evaluated on DD genotype frequency (p=<0.001). The ACE gene DD genotype and D allele frequencies were significantly higher in elderly hypertensive and diabetic hypertensive patients compared to healthy controls, indicating ACE gene deletion is a risk factor for hypertension but not specifically for diabetes.
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