Why the study?
Is the ACE insertion/deletion (I/D) polymorphism associated with hypertension and additive diseases in a North Indian population?
Population
440 adults from North India, mean age 50.35 and 47.32.
Comparison
ACE insertion/deletion polymorphism vs DD genotype / normotensive controls
Design
Case-control
Authors
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ACE ID genotype findings should not yet alter practice; leaves open causal role and need for prospective replication.
Is the ACE insertion/deletion (I/D) polymorphism associated with hypertension and additive diseases in a North Indian population?
The ACE insertion/deletion polymorphism, specifically the ID and II genotypes, is associated with an increased susceptibility to hypertension, cardiovascular diseases, and diabetes in the North Indian population.
Singh et al. (2016) studied this question.
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