Key result
ACE I/D polymorphism shows no association with essential hypertension despite higher DBP in II genotypes.
Why the study?
The association of ACE I/D polymorphism with essential hypertension in the Punjabi population was not well established.
Population
100 essential hypertensive patients and 100 normotensive controls from Punjab
Comparison
ACE I/D polymorphism genotypes in hypertensive patients vs normotensive controls
Design
Case-control study
Authors
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Should not guide hypertension risk assessment; leaves open modest II genotype effects on diastolic pressure for larger studies.
Case-Control (n=200)
Yes
p-value: p=>0.05
Randhawa et al. (2006) conducted a case-control in Essential hypertension (n=200). ACE I/D polymorphism vs. Normotensive controls was evaluated on Genotype frequency differences between hypertensive patients and normotensive controls (p=>0.05). The ACE I/D polymorphism was not significantly associated with essential hypertension, though diastolic blood pressure was significantly higher in the II genotype compared to DD (p<0.05).
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