Key result
The ACE insertion/deletion polymorphism was not significantly associated with an increased susceptibility to type 2 diabetes mellitus in a Saudi Arabian population.
Why the study?
The association between angiotensin-converting enzyme insertion/deletion polymorphism and type 2 diabetes mellitus development remains controversial.
Is the ACE insertion/deletion polymorphism associated with an increased susceptibility to type 2 diabetes in a Saudi population?
Case-Control (n=143)
No
Is the ACE insertion/deletion polymorphism associated with an increased susceptibility to type 2 diabetes in a Saudi population?
The ACE insertion/deletion polymorphism does not appear to be significantly associated with an increased risk of type 2 diabetes in this Saudi Arabian cohort.
No association of ACE I/D polymorphism with T2DM in Saudis; leaves open ethnic genetic variations for larger studies.
OBJECTIVES: The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the development of type 2 diabetes mellitus (T2DM) has been debated vigorously but still remains controversial. Therefore, the current study was designed to determine the possible association between ACE I/D polymorphism and T2DM and hypertension (HTN) in a population of Saudi Arabian participants. METHODS: A total of 143 individuals were recruited for the study, consisting of 74 controls and 69 patients with T2DM. Genotyping was performed via polymerase chain reaction. RESULTS: The genotype frequencies for DD, ID and II in controls were 52.7%, 39.2% and 8.1%, whereas in T2D patients it was 52.2%, 40.6% and 7.2% respectively. The DD frequency was highest out of the three genotypes in both the controls and the T2DM patients. CONCLUSION: There was no significant difference found in the genotype and allele frequencies between cases and controls, suggesting that insertion/deletion polymorphism in the ACE gene may not be associated with an increased susceptibility to type 2 diabetes in our study population.
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Habibullah et al. (2021) conducted a case-control in Type 2 Diabetes Mellitus (n=143). ACE insertion/deletion (I/D) polymorphism vs. Reference genotype (D/D) was evaluated on Association of ACE I/D polymorphism (I/D + I/I vs D/D genotypes) with Type 2 Diabetes Mellitus (OR 1.04, 95% CI 0.68-1.58, p=0.85). The ACE insertion/deletion polymorphism was not significantly associated with an increased susceptibility to type 2 diabetes mellitus in a Saudi Arabian population.
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