Key result
The ACE gene insertion/deletion polymorphism was not significantly associated with familial hypercholesterolemia in the Saudi population (OR 1.696).
Why the study?
Does the ACE gene I/D polymorphism predict the occurrence of familial hypercholesterolemia in the Saudi population?
Case-Control (n=128)
No
Does the ACE gene I/D polymorphism predict the occurrence of familial hypercholesterolemia in the Saudi population?
Odds Ratio: 1.696 (95% CI 0.7385–3.893)
Absolute Event Rate: 81.2% vs 71.9%
p-value: p=0.21
The ACE gene I/D polymorphism is not associated with the occurrence or diagnosis of familial hypercholesterolemia in the Saudi population.
ACE I/D polymorphism does not predict FH in Saudis; leaves open identification of other population-specific genetic markers.
BACKGROUND: The study of the association between genotype and phenotype is of great importance for the prediction of multiple diseases and pathophysiological conditions. The relationship between angiotensin converting enzyme (ACE) Insertion/Deletion (I/D) polymorphism and Familial Hypercholesterolemia (FH) has been not fully investigated in all the ethnicities. In this study we sought to determine the frequency of I/D polymorphism genotypes of ACE gene in Saudi patients with FH. RESULTS: This is a case-control study carried out purely in Saudi population. Genomic DNA was isolated from 128 subjects who have participated in this study. ACE gene I/D polymorphism was analyzed by polymerase chain reaction in 64 FH cases and 64 healthy controls. There was no statistically significant difference between the groups with respect to genotype distribution. Furthermore, we did not find any significant difference in the frequency of ACE I/D polymorphism in FH subjects when stratified by gender (p = 0.43). CONCLUSION: Our data suggest that ACE gene I/D polymorphism examined in this study has no role in predicting the occurrence and diagnosis of FH.
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Alharbi et al. (2013) conducted a case-control in Familial hypercholesterolemia (n=128). ACE gene insertion/deletion (I/D) polymorphism vs. Healthy controls was evaluated on Frequency of ACE I/D polymorphism genotypes (ID + DD vs II) (OR 1.696, 95% CI 0.7385-3.893, p=0.21). The ACE gene insertion/deletion polymorphism was not significantly associated with familial hypercholesterolemia in the Saudi population (OR 1.696).
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