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January 1, 2001Endocrine Research

The Dd Genotype of the Ace Gene Polymorphism Is Associated With Diabetic Nephropathy in Type-1 Diabetics

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Key result

The DD genotype of the ACE gene polymorphism is associated with the presence of diabetic nephropathy in patients with type-1 diabetes mellitus.

Why the study?

Is the DD genotype of the ACE gene polymorphism associated with diabetic nephropathy in type-1 diabetics?

Population

89 subjects: 52 type-1 diabetic patients with diabetic nephropathy, 10 type-1 diabetic patients with…

Comparison

DD genotype of the ACE gene polymorphism vs Healthy subjects and normoalbuminuric type-1…

Design

Case-control

Authors

SASami T. AzarUniversity of BalamandPZPierre ZallouaHarvard UniversityRMR. MedlejHôtel-Dieu de France

Discussion

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Implication

Does not support immediate clinical use of ACE genotyping; leaves open its value for nephropathy risk prediction in type-1 diabetes.

Study Design

Type

Case-Control (n=89)

Structured PICO

Is the DD genotype of the ACE gene polymorphism associated with diabetic nephropathy in type-1 diabetics?

P
Population
89 subjects comprising 52 type-1 diabetics with nephropathy, 10 type-1 diabetics with normoalbuminuria (>15 years duration), and 27 healthy controls.
E
Exposure
DD genotype of the ACE gene polymorphism
C
Comparator
Healthy subjects and normoalbuminuric type-1 diabetic patients
O
Outcome
Presence of diabetic nephropathy

The DD genotype of the ACE gene polymorphism is associated with an increased risk of diabetic nephropathy in patients with type-1 diabetes.

Cite This Study

Azar et al. (2001) conducted a case-control in Diabetic nephropathy in type-1 diabetes (n=89). DD genotype of the ACE gene polymorphism vs. Normoalbuminuric type-1 diabetics and healthy subjects was evaluated on Presence of diabetic nephropathy. The DD genotype of the ACE gene polymorphism is associated with the presence of diabetic nephropathy in patients with type-1 diabetes mellitus.

synapsesocial.com/papers/6a9430733fda5c29338c1709https://doi.org/10.1081/erc-100107173
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Also Consider

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  1. 1Polymorphisms of the angiotensin-converting-enzyme gene in subjects who die from coronary heart disease1994 · 216 citations
  2. 2Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus.1994 · 229 citations
  3. 3Deletion Polymorphism in the Angiotensin-Converting Enzyme Gene in Patients With a History of Ischemic Stroke1996 · 80 citations
  4. 4A Prospective Evaluation of an Angiotensin-Converting–Enzyme Gene Polymorphism and the Risk of Ischemic Heart Disease1995 · 910 citations
  5. 5Evidence for Association and Genetic Linkage of the Angiotensin-Converting Enzyme Locus With Hypertension and Blood Pressure in Men but Not Women in the Framingham Heart Study1998 · 555 citations