Key result
The ACE DD genotype was associated with a higher likelihood of severe glomerular basement membrane thickening (OR 6.11; 95% CI 1.84-20.3) and mesangial matrix expansion.
Why the study?
Is the ACE DD genotype associated with more severe diabetic glomerulopathy lesions in type 2 diabetic patients compared to II and ID genotypes?
Population
77 type 2 diabetic patients with an albumin excretion rate >= 20 microg/min
Comparison
ACE DD genotype vs ACE II and ID genotypes
Design
Cross-sectional
Authors
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May flag higher-risk type 2 diabetes patients for rapid nephropathy progression; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=77)
Is the ACE DD genotype associated with more severe diabetic glomerulopathy lesions in type 2 diabetic patients compared to II and ID genotypes?
Odds Ratio: 6.11 (95% CI 1.84–20.3)
The ACE DD genotype is independently associated with more severe diabetic glomerulopathy lesions in type 2 diabetes, suggesting it may help identify patients at higher risk for rapid progression of diabetic nephropathy.
Solini et al. (2002) conducted a cross-sectional in Type 2 diabetes with diabetic nephropathy (n=77). ACE DD genotype vs. ACE II and ID genotypes was evaluated on Likelihood of being in the highest tertile (III) vs lowest (I) for glomerular basement membrane (GBM) width (OR 6.11, 95% CI 1.84-20.3). The ACE DD genotype was associated with a higher likelihood of severe glomerular basement membrane thickening (OR 6.11; 95% CI 1.84-20.3) and mesangial matrix expansion.
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