Key result
The ACE gene DD genotype increased the risk of end-stage renal failure by 4.286-fold compared to the II genotype in Korean patients with type 2 diabetes.
Why the study?
Does the ACE gene DD genotype increase the risk of end-stage renal failure in Korean type 2 diabetic patients?
Population
191 Korean type 2 diabetic patients at extremes of renal risk, including an end-stage renal failure group on…
Comparison
ACE gene DD genotype vs ACE gene II or ID genotype
Design
Case-control
Authors
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Supports ACE genotyping for ESRD risk stratification in Korean T2DM; leaves open prospective validation before clinical adoption.
Cross-Sectional (n=191)
Does the ACE gene DD genotype increase the risk of end-stage renal failure in Korean type 2 diabetic patients?
Odds Ratio: 4.286 (95% CI 1.6–11.42)
p-value: p=0.005
The ACE gene DD genotype is significantly associated with an increased risk of progression to end-stage renal failure in Korean patients with type 2 diabetes.
Park et al. (2005) conducted a cross-sectional in Type 2 diabetes with end-stage renal failure (n=191). ACE gene DD genotype vs. ACE gene II genotype was evaluated on End-stage renal failure (ESRF) (OR 4.286, 95% CI 1.60-11.42, p=0.005). The ACE gene DD genotype increased the risk of end-stage renal failure by 4.286-fold compared to the II genotype in Korean patients with type 2 diabetes.
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