ACE Gene Polymorphism as a Prognostic Indicator in Patients With Type 2 Diabetes and Established Renal Disease
Why the study?
Does the DD genotype of the ACE gene polymorphism predict mortality and decline in renal function in patients with type 2 diabetes and established nephropathy?
Population
56 patients of Maltese Caucasian descent with type 2 diabetes and established nephropathy
Comparison
DD genotype of the ACE gene polymorphism vs ID or II genotype of the ACE gene polymorphism
Design
Cohort
Follow-up
3 years
Authors
Discussion
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Member takes
Implication
DD genotype may aid risk stratification in diabetic nephropathy; leaves open prospective validation before guiding care.
Structured PICO
Does the DD genotype of the ACE gene polymorphism predict mortality and decline in renal function in patients with type 2 diabetes and established nephropathy?
P
Population
56 patients of Maltese Caucasian descent with type 2 diabetes and established nephropathy
I
Intervention
DD genotype of the ACE gene polymorphism
C
Comparator
ID or II genotype of the ACE gene polymorphism
O
Outcome
Rate of change in calculated GFR and 3-year mortalityhard clinical
The DD genotype of the ACE gene is associated with a significantly faster decline in renal function and higher 3-year mortality in patients with type 2 diabetes and nephropathy.
Cite This Study
Fava et al. (2001) studied this question.