Why the study?
Is the ACE gene I/D polymorphism associated with the development of nephropathy in hypertensive patients?
Is the ACE gene I/D polymorphism associated with the development of nephropathy in hypertensive patients?
The ACE DD genotype is a genetic determinant for hypertensive renal disease, which may confound the association between hypertensive nephropathy and cardiovascular events.
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May link ACE I/D polymorphism to hypertensive nephropathy; hypothesis-generating and requires prospective validation before clinical adoption.
Kario et al. (1997) studied this question.
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