Key result
The ACE I/D polymorphism was not significantly associated with changes in glomerular filtration rate or urinary albumin excretion rate over 9 years in patients with NIDDM.
Why the study?
Is the ACE I/D polymorphism associated with the progression of diabetic nephropathy in patients with NIDDM?
Population
83 patients with non-insulin-dependent diabetes mellitus (NIDDM)
Comparison
ACE gene I/D polymorphism (DD genotype) vs ACE gene I/D polymorphism (II and ID genotypes)
Design
Cohort
Follow-up
9 years
Authors
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No association of ACE I/D with nephropathy progression in NIDDM; leaves open other genetic markers for diabetic kidney disease.
Cohort (n=83)
Is the ACE I/D polymorphism associated with the progression of diabetic nephropathy in patients with NIDDM?
p-value: p=NS
The ACE I/D polymorphism does not appear to be a major genetic marker for the progression of diabetic nephropathy in NIDDM patients over a 9-year follow-up.
Huang et al. (1998) conducted a cohort in Non-insulin-dependent diabetes mellitus (NIDDM) (n=83). ACE gene I/D polymorphism vs. Between genotype groups (II, ID, DD) was evaluated on Diabetic albuminuria and glomerular filtration rate (GFR) (p=NS). The ACE I/D polymorphism was not significantly associated with changes in glomerular filtration rate or urinary albumin excretion rate over 9 years in patients with NIDDM.
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