May 1, 1995Diabetes
Lack of Relationship Between an Insertion/Deletion Polymorphism in the Angiotensin I–Converting Enzyme Gene and Diabetic Nephropathy and Proliferative Retinopathy in IDDM Patients
Why the study?
Is the ACE gene insertion/deletion polymorphism associated with diabetic nephropathy or proliferative retinopathy in IDDM patients?
Population
390 insulin-dependent diabetes mellitus patients, including 198 with diabetic nephropathy and 192 with…
Comparison
Angiotensin-converting enzyme gene… vs Normoalbuminuria and no diabetic retinopathy
Design
Case-control
Authors
Discussion
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Member takes
Implication
ACE I/D polymorphism should not inform nephropathy risk stratification in IDDM; leaves open its role in other populations or complications.
Structured PICO
Is the ACE gene insertion/deletion polymorphism associated with diabetic nephropathy or proliferative retinopathy in IDDM patients?
P
Population
390 insulin-dependent diabetes mellitus (IDDM) patients, including 198 with diabetic nephropathy (121 men, 77 women, age 40.9 +/- 10 years) and 192 with normoalbuminuria (118 men, 74 women, age 42.7 +/- 10 years).
I
Intervention
Angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism
C
Comparator
Normoalbuminuria (for nephropathy comparison) and no diabetic retinopathy (for retinopathy comparison)
O
Outcome
Genotype distribution of the ACE I/D polymorphismsurrogate
The ACE gene insertion/deletion polymorphism is not associated with the development of diabetic nephropathy or proliferative retinopathy in patients with insulin-dependent diabetes mellitus.
Cite This Study
Tarnow et al. (1995) studied this question.