Key result
ACE gene I/D and PstI polymorphisms showed no significant association with the development of nephropathy in patients with non-insulin dependent diabetes mellitus.
Why the study?
Is there an association between ACE gene I/D and PstI polymorphisms and the development of nephropathy in patients with NIDDM?
Population
941 patients with non-insulin dependent diabetes mellitus, including a selected analysis cohort of 127…
Comparison
Presence of angiotensin I-converting enzyme gene… vs Normoalbuminuric NIDDM patients (control group).
Design
Case-control
Authors
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No association seen in this case-control study; leaves open ACE polymorphism contributions to diabetic nephropathy and requires larger prospective confirmation.
Case-Control (n=941)
Is there an association between ACE gene I/D and PstI polymorphisms and the development of nephropathy in patients with NIDDM?
This study suggests that there is no significant association between the ACE gene I/D and PstI polymorphisms and the susceptibility to diabetic nephropathy in patients with type 2 diabetes.
Grzeszczak et al. (1998) conducted a case-control in Non-insulin dependent diabetes mellitus (NIDDM) and nephropathy (n=941). ACE gene I/D and PstI polymorphisms vs. Normoalbuminuric NIDDM patients (controls) was evaluated on Distribution of ACE I/D and PstI genotypes or allele frequencies. ACE gene I/D and PstI polymorphisms showed no significant association with the development of nephropathy in patients with non-insulin dependent diabetes mellitus.
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