Why the study?
Is the ACE-insertion/deletion polymorphism associated with diabetic nephropathy in patients with diabetes mellitus?
Population
5336 patients with insulin-dependent or non-insulin-dependent diabetes mellitus from 19 studies in 21…
Comparison
Presence of ACE-insertion/deletion polymorphism vs Absence of ACE-insertion/deletion polymorphism
Design
Systematic_review
Authors
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Ethnic differences in ACE I/D-nephropathy association warrant caution in generalization; leaves open ancestry-specific validation in NIDDM.
Is the ACE-insertion/deletion polymorphism associated with diabetic nephropathy in patients with diabetes mellitus?
The ACE-insertion/deletion polymorphism may be associated with diabetic nephropathy in Asian patients with NIDDM, but not in Caucasian patients.
Kunz et al. (1998) studied this question.
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