Key result
The ACE DD genotype was associated with significant odds ratios for coronary heart disease, myocardial infarction, and renal disease, though specific quantitative estimates were not reported.
Why the study?
Does the ACE gene insertion/deletion polymorphism impact susceptibility to cardiovascular and renal disease in patients with diabetes mellitus?
Population
Individuals with Type 1 and Type 2 diabetes mellitus (DM) and nondiabetic subjects
Design
Meta-analysis
Authors
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ACE DD genotype may flag higher-risk diabetic patients; leaves open prospective validation before guiding therapy or genotyping.
Meta-Analysis
Does the ACE gene insertion/deletion polymorphism impact susceptibility to cardiovascular and renal disease in patients with diabetes mellitus?
The ACE DD genotype is associated with increased susceptibility to coronary heart disease, myocardial infarction, and renal disease, and may identify individuals resistant to ACE inhibitors.
Kennon et al. (1999) conducted a meta-analysis in Type 1 and Type 2 diabetes mellitus. ACE gene insertion/deletion polymorphism (DD genotype) was evaluated on Disease susceptibility (coronary heart disease, myocardial infarction, and renal disease). The ACE DD genotype was associated with significant odds ratios for coronary heart disease, myocardial infarction, and renal disease, though specific quantitative estimates were not reported.
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