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April 26, 1994Proceedings of the National Academy of SciencesOpen Access

Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus.

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Why the study?

Is the D allele of the ACE gene associated with an increased risk of coronary heart disease in patients with non-insulin-dependent diabetes mellitus?

Population

316 unrelated individuals with non-insulin-dependent diabetes mellitus, including 132 with myocardial…

Comparison

Presence of the D allele of the… vs Absence of the D allele (non-carriers)

Design

Case-control

Authors

JRJosé Saturnino Monroy RuizFondation Jean Dausset-CEPHHBHélène BlanchéFondation Jean Dausset-CEPHNCNoah D. CohenTexas College

Discussion

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Implication

Supports ACE D allele in CHD risk assessment for type 2 diabetes; leaves open prospective validation before clinical use.

Structured PICO

Is the D allele of the ACE gene associated with an increased risk of coronary heart disease in patients with non-insulin-dependent diabetes mellitus?

P
Population
316 unrelated individuals with non-insulin-dependent diabetes mellitus (NIDDM), including 132 with myocardial infarction or significant coronary stenoses and 184 with no history of coronary heart disease (CHD).
I
Intervention
Presence of the D allele (deletion polymorphism) of the angiotensin-converting enzyme (ACE) gene
C
Comparator
Absence of the D allele (non-carriers)
O
Outcome
Presence of coronary heart disease (myocardial infarction or significant coronary stenoses)hard clinical

The D allele of the ACE gene is a strong, independent genetic risk factor for early-onset coronary heart disease in patients with non-insulin-dependent diabetes mellitus.

Cite This Study

Ruiz et al. (1994) studied this question.

synapsesocial.com/papers/6a70461435aa2c282ce1929dhttps://doi.org/10.1073/pnas.91.9.3662
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diabetes, Other Risk Factors, and 12-Yr Cardiovascular Mortality for Men Screened in the Multiple Risk Factor Intervention Trial1993 · 4,104 citations
  2. 2Balloon angioplasty enhances the expression of angiotensin II AT1 receptors in neointima of rat aorta.1992 · 151 citations
  3. 3Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction1992 · 5,954 citations
  4. 4PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)1992 · 1,249 citations
  5. 5Stimulation of plasminogen activator inhibitor in vivo by infusion of angiotensin II. Evidence of a potential interaction between the renin-angiotensin system and fibrinolytic function.1993 · 406 citations