Key result
Carriers of the Xba I/Dde I '+ =' haplotype at the ACE locus had a significantly increased risk of developing diabetic nephropathy (OR 4.0; 95% CI 1.5-11.0).
Why the study?
Are ACE gene polymorphisms associated with an increased risk of diabetic nephropathy in patients with insulin-dependent diabetes mellitus?
Population
151 insulin-dependent diabetes mellitus patients with a diabetes duration of 16-21 years, including 74 cases…
Comparison
Angiotensin I-converting enzyme gene… vs Normoalbuminuric control subjects.
Design
Case-control
Authors
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Cautions against routine ACE genotyping in diabetes; leaves open replication and prospective validation of nephropathy risk.
Case-Control (n=151)
Are ACE gene polymorphisms associated with an increased risk of diabetic nephropathy in patients with insulin-dependent diabetes mellitus?
Odds Ratio: 4 (95% CI 1.5–11)
Specific ACE gene polymorphisms, particularly the Xba I/Dde I '+ =' haplotype, are associated with a significantly increased risk of developing diabetic nephropathy in patients with insulin-dependent diabetes mellitus.
Doria et al. (1994) conducted a case-control in Diabetic nephropathy in insulin-dependent diabetes mellitus (n=151). Xba I/Dde I '+ =' haplotype at the ACE locus vs. Non-carriers was evaluated on Diabetic nephropathy (OR 4.0, 95% CI 1.5-11.0). Carriers of the Xba I/Dde I '+ =' haplotype at the ACE locus had a significantly increased risk of developing diabetic nephropathy (OR 4.0; 95% CI 1.5-11.0).
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