Key result
The II genotype of the ACE gene was associated with a reduced risk for diabetic nephropathy (P=0.006), while plasma ACE levels were higher in subjects with nephropathy (P=0.0022).
Why the study?
Is the ACE gene insertion/deletion polymorphism or plasma ACE level associated with the risk of diabetic retinopathy or nephropathy in patients with insulin-dependent diabetes mellitus?
Case-Control (n=181)
Is the ACE gene insertion/deletion polymorphism or plasma ACE level associated with the risk of diabetic retinopathy or nephropathy in patients with insulin-dependent diabetes mellitus?
p-value: p=0.006
The II genotype of the ACE gene serves as a marker for reduced risk of diabetic nephropathy in patients with insulin-dependent diabetes mellitus.
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May aid nephropathy risk stratification in IDDM; leaves open prospective validation before clinical use.
Marre et al. (1994) conducted a case-control in Insulin-dependent diabetes mellitus (IDDM) (n=181). ACE gene insertion/deletion polymorphism and plasma ACE levels vs. IDDM subjects without nephropathy or with other ACE genotypes was evaluated on Diabetic nephropathy (p=0.006). The II genotype of the ACE gene was associated with a reduced risk for diabetic nephropathy (P=0.006), while plasma ACE levels were higher in subjects with nephropathy (P=0.0022).
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