Key result
The ACE gene D allele independently increased the odds of having macroalbuminuria versus microalbuminuria approximately threefold (p<0.01) in Iranian patients with type 2 diabetes.
Why the study?
Is the ACE gene I/D polymorphism associated with the development and progression of albuminuria in Iranian patients with type 2 diabetes?
Population
322 Iranian patients with type 2 diabetes, categorized into normoalbuminuria, microalbuminuria and…
Comparison
ACE gene I/D polymorphism (D allele) vs ACE gene I/D polymorphism (I allele / II genotype)
Design
Cross-sectional
Authors
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The ACE D allele was associated with macroalbuminuria progression in Iranian T2D; leaves open whether genotyping aids risk stratification pending prospective validation.
Cross-Sectional (n=322)
Is the ACE gene I/D polymorphism associated with the development and progression of albuminuria in Iranian patients with type 2 diabetes?
Odds Ratio: 3
p-value: p=<0.01
In Iranian patients with type 2 diabetes, the ACE gene D allele is associated with the progression to macroalbuminuria, but not the initial development of microalbuminuria.
Nikzamir et al. (2009) conducted a cross-sectional in Type 2 diabetes (n=322). ACE gene I/D polymorphism (D allele) vs. Non-D allele / other genotypes was evaluated on Progression to macroalbuminuria versus microalbuminuria (OR ~3, p=<0.01). The ACE gene D allele independently increased the odds of having macroalbuminuria versus microalbuminuria approximately threefold (p<0.01) in Iranian patients with type 2 diabetes.
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