Key result
The ACE gene DD genotype was not significantly associated with the presence of diabetic nephropathy in patients with type 2 diabetes (OR 0.313, p=0.076).
Why the study?
Does the ACE gene I/D polymorphism associate with the development of diabetic nephropathy in patients with type 2 diabetes?
Case-Control (n=58)
Yes
Does the ACE gene I/D polymorphism associate with the development of diabetic nephropathy in patients with type 2 diabetes?
Odds Ratio: 0.313 (95% CI 0.084–1.164)
Absolute Event Rate: 40.9% vs 19.4%
p-value: p=0.076
The ACE I/D polymorphism was not significantly associated with the presence of diabetic nephropathy in this small cohort of patients with type 2 diabetes.
No significant association in this small case-control study; leaves open ACE I/D polymorphism's role in diabetic nephropathy.
Aim: to study the relation of angiotensin-converting enzyme ACE (I/D) in genetic susceptibility of diabetic nephropathy (DN). Methods. I/D polymorphism of ACE gene was studied in 58 patients with diabetes type 2. Results. There are no reliable differences in detection of DD genotype and D allele in patients with DN and without DN (40,9 and 52,3 %, 19,4 and 41,7 %, respectively) (p = 0,076, LR = 0,313, 95 % DI = 0,084-1,164 for DD and p = 0,266, LR = 0,631, 95 % DI = 0,303-1,312 for D). Conclusion. The comparison of the results of genotyping in patients with and without DN did not reveal any differences in distribution of allele and ACE genotypes.
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Vasilkova et al. (2014) conducted a case-control in Type 2 diabetes mellitus, diabetic nephropathy (n=58). ACE gene I/D polymorphism (DD genotype) vs. Non-DD genotypes was evaluated on Frequency of DD genotype in patients with vs without diabetic nephropathy (OR 0.313, 95% CI 0.084-1.164, p=0.076). The ACE gene DD genotype was not significantly associated with the presence of diabetic nephropathy in patients with type 2 diabetes (OR 0.313, p=0.076).
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