Key result
The ACE DD genotype was significantly associated with increased susceptibility to end-stage renal disease in patients with diabetic nephropathy (OR 1.67; 95% CI 1.25-2.21; P=0.0004).
Why the study?
Is the ACE I/D gene polymorphism associated with increased risk of ESRD in patients with diabetic nephropathy?
Population
Patients with diabetic nephropathy (DN) from 12 studies
Comparison
ACE I/D gene polymorphism vs Other ACE genotypes (I allele or II/ID genotypes)
Design
Meta-analysis
Authors
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May inform ESRD risk stratification in diabetic nephropathy; confirms association but should not yet change practice.
Meta-Analysis
Is the ACE I/D gene polymorphism associated with increased risk of ESRD in patients with diabetic nephropathy?
Odds Ratio: 1.67 (95% CI 1.25–2.21)
p-value: p=0.0004
The ACE D allele and DD genotype are associated with an increased risk of developing end-stage renal disease in patients with diabetic nephropathy.
Yu et al. (2012) conducted a meta-analysis in Diabetic nephropathy and end-stage renal disease. ACE I/D gene polymorphism (DD genotype) vs. Non-DD genotype was evaluated on End-stage renal disease susceptibility (OR 1.67, 95% CI 1.25-2.21, p=0.0004). The ACE DD genotype was significantly associated with increased susceptibility to end-stage renal disease in patients with diabetic nephropathy (OR 1.67; 95% CI 1.25-2.21; P=0.0004).
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