Key result
The ACE D allele and DD genotype were significantly associated with end-stage renal disease susceptibility in patients with IgA nephropathy (p=0.01 and p=0.003, respectively).
Why the study?
Is the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism associated with end-stage renal disease (ESRD) risk in IgA nephropathy patients?
Meta-Analysis
Is the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism associated with end-stage renal disease (ESRD) risk in IgA nephropathy patients?
p-value: p=0.01 and 0.003
The DD homozygote of the ACE gene is a significant genetic marker for the onset of ESRD in patients with IgA nephropathy.
Supports ACE I/D genotyping for ESRD risk stratification in IgA nephropathy; reinforces genetic marker evidence from meta-analysis.
BACKGROUND AND OBJECTIVE: The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk in IgA nephropathy (IgAN) patients is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and ESRD susceptibility in IgAN patients. METHOD: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. RESULTS: Thirteen articles were identified for the analysis of the association between ACE I/D gene polymorphism and ESRD risk in IgAN patients. D allele and DD genotype were associated with ESRD susceptibility in IgAN patients for overall populations (p=0.01 and 0.003, respectively). In Asians, there was a markedly positive association between DD genotype and ESRD susceptibility (p=0.03). Furthermore, D allele and DD genotype were associated with ESRD susceptibility in Caucasians (p=0.02 and 0.03, respectively). However, II genotype might not play a protective role against ESRD onset for overall populations, Asians and Caucasians. CONCLUSION: DD homozygote is a significant genetic molecular marker for the onset of ESRD in IgAN patients.
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Zhou et al. (2012) conducted a meta-analysis in IgA nephropathy. ACE insertion/deletion (I/D) gene polymorphism (D allele and DD genotype) vs. II genotype was evaluated on End-stage renal disease (ESRD) susceptibility (p=0.01 and 0.003). The ACE D allele and DD genotype were significantly associated with end-stage renal disease susceptibility in patients with IgA nephropathy (p=0.01 and p=0.003, respectively).
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