Key result
ACE I/D gene polymorphism shows no association with SSNS susceptibility in children.
Why the study?
The association between ACE insertion/deletion gene polymorphism and steroid-sensitive nephrotic syndrome risk in children remains controversial.
Is the ACE I/D gene polymorphism associated with steroid-sensitive nephrotic syndrome susceptibility in children?
Meta-Analysis
Is the ACE I/D gene polymorphism associated with steroid-sensitive nephrotic syndrome susceptibility in children?
Odds Ratio: 1.24
p-value: p=0.28
The ACE I/D gene polymorphism does not appear to be associated with susceptibility to steroid-sensitive nephrotic syndrome in children.
Does not support ACE I/D testing for SSNS risk assessment in children; challenges prior candidate-gene reports and supports broader genomic investigation.
BACKGROUND AND OBJECTIVE: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism correlates with circulating and cellular ACE concentration. Association between ACE I/D gene polymorphism and steroid-sensitive nephrotic syndrome (SSNS) risk in children is still controversial. This meta-analysis was performed to evaluate the relation between ACE I/D gene polymorphism and SSNS susceptibility in children. METHODS: The relevant investigations were screened from the search engines of PubMed, Cochrane Library and CBM-disc (China Biological Medicine Database) as of 1 March 2011, and eligible studies were synthesized using meta-analysis methods. RESULTS: Ten studies were identified for the analysis of association between ACE I/D gene polymorphism and SSNS risk in children, including seven in Asians, one for Caucasians and two in Africans. There was no markedly positive association between D allele or DD genotype and SSNS susceptibility in Asians, Caucasians and Africans (D: Asians OR = 1.24, p = 0.28; Caucasians OR = 1.61, p = 0.15; Africans OR = 1.61, p = 0.53; DD: Asians OR = 1.72, p = 0.15; Caucasians OR = 1.39, p = 0.48; Africans OR = 1.80, p = 0.56). Furthermore, II homozygous seemed not to play a protective role against SSNS onset for Asians, Caucasians and Africans (Asians OR = 0.95, p = 0.85; Caucasians OR = 0.30, p = 0.11; Africans OR = 0.60, p = 0.65). CONCLUSIONS: There was no association between ACE I/D gene polymorphism and SSNS susceptibility in Asians, Caucasians and Africans. However, the conclusions for Caucasians and Africans were less powerful.
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Zhou et al. (2011) conducted a meta-analysis in Steroid-sensitive nephrotic syndrome (SSNS). Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism vs. Alternative alleles/genotypes was evaluated on Steroid-sensitive nephrotic syndrome (SSNS) susceptibility (OR 1.24, p=0.28). ACE I/D gene polymorphism was not significantly associated with SSNS susceptibility in Asian (D allele OR 1.24, p=0.28), Caucasian (OR 1.61, p=0.15), or African (OR 1.61, p=0.53) children.
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