Key result
The ACE gene D allele and DD genotype were not significantly associated with steroid-resistant nephrotic syndrome risk in Asian (OR 1.60, p=0.26) or Caucasian children.
Why the study?
Is the ACE gene insertion/deletion (I/D) polymorphism associated with steroid-resistant nephrotic syndrome (SRNS) risk in children?
Population
Children with steroid-resistant nephrotic syndrome across 7 investigations
Comparison
Angiotensin-converting enzyme gene… vs Other ACE gene alleles/genotypes
Design
Meta-analysis
Authors
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Does not support ACE genotyping for SRNS risk assessment in Asian or Caucasian children; leaves open ancestry-specific effects and needs prospective validation.
Meta-Analysis
Is the ACE gene insertion/deletion (I/D) polymorphism associated with steroid-resistant nephrotic syndrome (SRNS) risk in children?
Odds Ratio: 1.6
p-value: p=0.26
The ACE gene D allele and DD genotype do not appear to be significant genetic markers for SRNS development in Asian and Caucasian children, though the D allele may be associated with risk in African children.
Zhou et al. (2011) conducted a meta-analysis in Steroid-resistant nephrotic syndrome (SRNS). ACE gene insertion/deletion (I/D) polymorphism vs. Other genotypes was evaluated on Steroid-resistant nephrotic syndrome (SRNS) susceptibility (D allele in Asians) (OR 1.60, p=0.26). The ACE gene D allele and DD genotype were not significantly associated with steroid-resistant nephrotic syndrome risk in Asian (OR 1.60, p=0.26) or Caucasian children.
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