Key result
The ACE DD genotype was significantly associated with increased risk of IgA nephropathy susceptibility (OR 2.37; 95% CI 1.04-5.41) and progression (OR 1.75; 95% CI 1.24-2.56) in Asian populations.
Why the study?
Is the ACE gene insertion/deletion polymorphism associated with IgA nephropathy susceptibility and progression?
Meta-Analysis
Is the ACE gene insertion/deletion polymorphism associated with IgA nephropathy susceptibility and progression?
Odds Ratio: 2.37 (95% CI 1.04–5.41)
The ACE I/D polymorphism, specifically the DD genotype, is associated with IgA nephropathy progression in both Asians and Caucasians, and with susceptibility in Asians.
BACKGROUND/AIMS: The angiotensin I-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been extensively examined for the association with immunoglobulin A (IgA) nephropathy (IgAN), however, conflicting results have occurred. We performed a meta-analysis to evaluate the association of ACE I/D polymorphism with IgAN in different ethnic groups. METHODS: 11 studies testing the association between ACE I/D polymorphism and IgAN susceptibility, and 9 studies testing the association of ACE I/D with IgAN progression were used in this analysis. The overall odds ratio (OR) was estimated by a fixed or random effect model. RESULTS: The overall OR for the risk of susceptibility and progression of IgAN in Asians for the DD genotype is 2.37 (95% CI 1.04-5.41) and 1.75 (95% CI 1.24-2.56). The overall OR for the D allele in Asians also showed a similar magnitude, though without statistical significance (p = 0.09, p = 0.13, respectively). In Caucasians, both the DD genotype and D allele were associated with IgAN progression (OR 1.90, 1.61, respectively), but not IgAN susceptibility (p = 0.30, p = 0.41, respectively). CONCLUSION: Our findings support the notion that ACE I/D polymorphism is associated with IgAN. Meanwhile, the role of ACE I/D polymorphism in Asians is different from that of Caucasians.
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Du et al. (2006) conducted a meta-analysis in IgA nephropathy. ACE gene insertion/deletion (I/D) polymorphism vs. Other ACE genotypes was evaluated on Risk of susceptibility to IgAN in Asians for the DD genotype (OR 2.37, 95% CI 1.04-5.41). The ACE DD genotype was significantly associated with increased risk of IgA nephropathy susceptibility (OR 2.37; 95% CI 1.04-5.41) and progression (OR 1.75; 95% CI 1.24-2.56) in Asian populations.
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