Key result
The D allele of the ACE I/D polymorphism was significantly associated with increased susceptibility to all types of aortic aneurysms (OR 1.378; 95% CI 1.103-1.723; p=0.005).
Why the study?
Is the insertion/deletion polymorphism of the angiotensin-converting enzyme associated with susceptibility to aortic aneurysms?
Meta-Analysis (n=5,466)
Is the insertion/deletion polymorphism of the angiotensin-converting enzyme associated with susceptibility to aortic aneurysms?
Odds Ratio: 1.378 (95% CI 1.103–1.723)
p-value: p=0.005
The ACE I/D polymorphism, specifically the D allele, is associated with an increased susceptibility to abdominal aortic aneurysms in European populations.
INTRODUCTION: The purpose of this study is to examine whether the insertion (I) and deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) confers susceptibility to aortic aneurysms (AAs). MATERIALS AND METHODS: A meta-analysis was conducted on the associations between the ACE I/D polymorphism and all AAs and abdominal aortic aneurysms (AAAs). RESULTS: Ten studies consisting of 2784 cases and 2682 controls were available for the meta-analysis. Meta-analysis showed a significant association between the D allele and all types of AA (OR 1.378, 95% CI 1.103-1.723, p = 0.005) and AAA (OR 1.274, 95% CI 1.004-1.617, p = 0.046). Meta-analysis of both the DD genotype and the DD vs. II genotype showed an association with AAAs. Stratification by ethnicity indicated an association between the D allele of the ACE I/D polymorphism and AAAs in Europeans (OR = 1.338, 95% CI = 1.026-1.745, p = 0.031), but not in Asians (OR = 0.927, 95% CI = 0.660-1.303, p = 0.663). Furthermore, analysis using the recessive model, dominant model, and homozygote contrast all showed the same pattern for the D allele. CONCLUSIONS: Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to AAAs in European populations.
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Song et al. (2013) conducted a meta-analysis in Aortic aneurysms (n=5,466). ACE I/D polymorphism (D allele) vs. I allele / II genotype was evaluated on All types of aortic aneurysms (OR 1.378, 95% CI 1.103-1.723, p=0.005). The D allele of the ACE I/D polymorphism was significantly associated with increased susceptibility to all types of aortic aneurysms (OR 1.378; 95% CI 1.103-1.723; p=0.005).
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