Key result
In patients with Type 2 diabetes for ≤10 years, the D allele (DD/ID) was associated with increased odds of incipient (OR 2.66; 95% CI 1.12-6.58) and overt diabetic nephropathy.
Why the study?
Does the presence of the D allele of the ACE gene increase the risk of diabetic nephropathy in patients with Type 2 diabetes mellitus?
Population
982 patients with Type 2 diabetes mellitus, categorized by urinary albumin excretion and diabetes duration.
Comparison
Presence of the D allele of the… vs II genotype of the ACE gene
Design
Cross-sectional
Authors
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May support early nephropathy risk stratification in recent-onset T2DM; leaves open prospective validation before clinical adoption.
Cross-Sectional (n=982)
Does the presence of the D allele of the ACE gene increase the risk of diabetic nephropathy in patients with Type 2 diabetes mellitus?
Odds Ratio: 2.66 (95% CI 1.12–6.58)
p-value: p=0.015
The D allele of the ACE gene is associated with an increased risk of incipient and overt diabetic nephropathy specifically in patients with a shorter duration (≤ 10 years) of Type 2 diabetes.
Canani et al. (2005) conducted a cross-sectional in Type 2 diabetes mellitus (n=982). Presence of the D allele (DD/ID genotype) of the ACE gene vs. II genotype was evaluated on Incipient diabetic nephropathy in patients with diabetes duration ≤10 years (OR 2.66, 95% CI 1.12-6.58, p=0.015). In patients with Type 2 diabetes for ≤10 years, the D allele (DD/ID) was associated with increased odds of incipient (OR 2.66; 95% CI 1.12-6.58) and overt diabetic nephropathy.
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