Correlation of ACE gene deletion/insertion polymorphism and risk of pregnancy-induced hypertension: a meta-analysis based on 10,236 subjects

OBJECTIVES: To clarify the association of angiotensin-converting enzyme (ACE) gene deletion/insertion polymorphism with risk of pregnancy-induced hypertension. METHODS: We systematically searched China National Knowledge Infrastructure, Wanfang database, Chongqing WeiPu database and PubMed up to March 2014 to collect related case-control studies. RevMan 5.0 software was used for meta-analysis after evaluating the quality of enrolled studies and extracting the data. RESULTS: A total of 45 case-control studies was selected, including 10,236 subjects. The meta-analysis was assessed by odds ratios (ORs) and 95% confidence intervals (CIs) after genotype consolidation. In total, D allele vs I allele: OR 1.57, 95% CI 1.33-1.86; genotype DD vs genotype II + DI: OR 1.86, 95% CI 1.48-2.32; genotype II vs genotype DI + DD: OR 0.65, 95% CI 0.53-0.80. In the Asian population, D allele vs I allele: OR 1.80, 95% CI 1.36-2.38; genotype DD vs genotype II + DI: OR 2.25, 95% CI 1.53-3.30; genotype II vs genotype DI + DD: OR 0.56, 95% CI 0.41-0.76. In the Caucasian population, D allele vs. I allele: OR 1.24, 95% CI 1.08-1.44; genotype DD vs. genotype II + DI: OR 1.25, 95% CI 1.10-1.41; genotype II vs. genotype DI + DD: OR 0.96, 95% CI 0.83-1.11. CONCLUSION: The ACE gene insertion/deletion polymorphism is associated with the risk of pregnancy-induced hypertension.