Key result
The ACE DD genotype was significantly associated with pregnancy-induced hypertension, occurring in 60% of cases versus 30% of normotensive controls (OR 3.5, P=0.004).
Why the study?
Is ACE gene polymorphism associated with an increased risk of pregnancy-induced hypertension in primigravidae?
Population
100 primigravidae, comprising 50 with pregnancy-induced hypertension (PIH) and 50 normotensive controls.
Comparison
ACE gene polymorphism and serum ACE activity vs Normotensive primigravidae and non-DD genotypes
Design
Case-control
Follow-up
up to delivery
Authors
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ACE DD genotype may increase PIH risk in primigravidae; hypothesis-generating and should not yet change practice or screening.
Case-Control (n=100)
Is ACE gene polymorphism associated with an increased risk of pregnancy-induced hypertension in primigravidae?
Odds Ratio: 3.5
Absolute Event Rate: 60% vs 30%
p-value: p=0.004
The ACE DD genotype and D allele are associated with an increased risk of pregnancy-induced hypertension, though they do not correlate with disease severity or perinatal outcomes.
Kaur et al. (2005) conducted a case-control in Pregnancy-induced hypertension (n=100). ACE DD genotype vs. Non-DD genotype was evaluated on Pregnancy-induced hypertension (OR 3.5, p=0.004). The ACE DD genotype was significantly associated with pregnancy-induced hypertension, occurring in 60% of cases versus 30% of normotensive controls (OR 3.5, P=0.004).
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