Why the study?
Is the ACE gene insertion/deletion (I/D) polymorphism associated with an increased risk of pregnancy hypertensive disorders?
Population
30 case-control studies pooling 3523 cases with pregnancy hypertensive disorders (PHDs) and 4817 controls
Comparison
Angiotensin-converting enzyme gene… vs Controls without pregnancy hypertensive…
Design
Meta-analysis
Authors
Loading...
May aid risk stratification in Asian and Caucasian women; leaves open prospective validation before clinical adoption.
Is the ACE gene insertion/deletion (I/D) polymorphism associated with an increased risk of pregnancy hypertensive disorders?
The DD genotype of the ACE I/D polymorphism is a genetic risk factor for pregnancy hypertensive disorders, particularly pre-eclampsia in Asian and Caucasian populations.
Chen et al. (2011) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: