Key result
The ACE I/D genotype was significantly associated with a history of foetal loss when compared to patient controls (OR 1.52, p<0.02) and healthy controls (OR 1.48, p=0.02).
Why the study?
Is the ACE I/D genotype associated with a history of foetal loss or uteroplacental dysfunction in women?
Population
1,504 women, including 312 with a history of foetal loss, 112 with uteroplacental dysfunction, 527 patient…
Comparison
Presence of angiotensin-converting enzyme intron… vs Control groups
Design
Case-control
Authors
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Supports RAS role in pregnancy loss; hypothesis-generating and should not yet change practice.
Case-Control (n=1,504)
Is the ACE I/D genotype associated with a history of foetal loss or uteroplacental dysfunction in women?
Odds Ratio: 1.52
p-value: p=<0.02
The ACE I/D polymorphism is significantly associated with a history of foetal loss, suggesting involvement of the renin-angiotensin system in pregnancy complications.
Bukreeva et al. (2009) conducted a case-control in History of foetal loss or uteroplacental dysfunction (n=1,504). ACE I/D genotype vs. Controls (patient controls and healthy controls) was evaluated on History of foetal loss (OR 1.52, p=<0.02). The ACE I/D genotype was significantly associated with a history of foetal loss when compared to patient controls (OR 1.52, p<0.02) and healthy controls (OR 1.48, p=0.02).
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