What question did this study set out to answer?

To evaluate the prevalence and association of ten polymorphisms across seven thrombophilia-related genes with recurrent pregnancy loss.

April 15, 2018Systems Biology in Reproductive MedicineOpen Access

Association between thrombophilia gene polymorphisms and recurrent pregnancy loss risk in the Iranian population

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To evaluate the prevalence and association of ten polymorphisms across seven thrombophilia-related genes with recurrent pregnancy loss.
Conducted a case-control study in Iran comprising 200 women with recurrent pregnancy loss and 200 control women with at least one successful pregnancy.
Genotyped ten polymorphisms across seven genes (FV, FXIII, FII, BF, ITGB3, MTHFR, and PAI-1) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
Significant positive associations with recurrent pregnancy loss were observed for BF (-455 G/A), MTHFR (677 C/T and 1298 A/C), PAI-1 (-675 I/D, 4G/5G), FV Leiden, FV (A5279G), and FXIII (Val34Leu) polymorphisms.
ITGB3 (1565 T/C) demonstrated a negative (protective) association with recurrent pregnancy loss risk.
No statistically significant associations were identified between recurrent pregnancy loss and the FII (A20210G) or FV (A4070G) polymorphisms.

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Implication

Case-control study reveals associations between specific thrombophilia gene variants and recurrent miscarriage in women, highlighting the clinical value of screening.

Cite This Study

Bigdeli et al. (2018) studied this question.

synapsesocial.com/papers/6a7564aa96d04a2f43f59558 https://doi.org/10.1080/19396368.2018.1456576

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Implication

Case-control study reveals associations between specific thrombophilia gene variants and recurrent miscarriage in women, highlighting the clinical value of screening.

Association between thrombophilia gene polymorphisms and recurrent pregnancy loss risk in the Iranian population

Key Points

Discussion

Implication

Cite This Study

Association between thrombophilia gene polymorphisms and recurrent pregnancy loss risk in the Iranian population

Key Points

Discussion

Implication

Cite This Study

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