Key result
Early intravenous immunoglobulin, vaccinia immunoglobulin, and corticosteroids led to full recovery in severe postvaccinial encephalitis with acute disseminated encephalomyelitis.
Why the study?
Does early treatment with intravenous immunoglobulin, high-dose steroids, and vaccinia immunoglobulin improve recovery in severe postvaccinial encephalitis with acute disseminated encephalomyelitis?
Does early treatment with intravenous immunoglobulin, high-dose steroids, and vaccinia immunoglobulin improve recovery in severe postvaccinial encephalitis with acute disseminated encephalomyelitis?
Early intervention with intravenous immunoglobulin, high-dose steroids, and vaccinia immunoglobulin may lead to full recovery in patients with severe postvaccinial encephalitis with acute disseminated encephalomyelitis.
May support early combined immunotherapy in severe postvaccinial encephalitis; hypothesis-generating and requires prospective validation.
We report the second case of severe postvaccinial encephalitis with acute disseminated encephalomyelitis since smallpox vaccination was reintroduced in 2002. Both affected patients responded dramatically with early intervention of intravenous immunoglobulin. Our patient, who also received concurrent vaccinia immunoglobulin and corticosteroids, demonstrated full recovery.
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Dam et al. (2009) studied this question. Early intravenous immunoglobulin, vaccinia immunoglobulin, and corticosteroids led to full recovery in severe postvaccinial encephalitis with acute disseminated encephalomyelitis.
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