Key result
Human monoclonal antibodies represent a promising strategy for treating and preventing viral infections in pediatric populations, though challenges in development for newborns and children remain.
Why the study?
Many viral pathogens still lack effective vaccines, highlighting the need for strategies such as human monoclonal antibodies to prevent and treat pediatric viral infections.
Monoclonal antibodies represent a promising strategy for preventing and treating viral infections in children, though significant developmental challenges remain.
Should not yet change pediatric practice; leaves open key development gaps for newborns and infants.
Medical advancements over the last century have improved our ability to treat pediatric infectious diseases, significantly reducing associated morbidity and mortality worldwide. Although vaccines have been pivotal in this progress, many viral pathogens still do not currently have effective vaccines. The COVID-19 pandemic highlighted the need for rapid responses to emerging viral pathogens and introduced new tools to combat them. This review addresses human monoclonal antibodies (mAbs) as a strategy for treating and preventing viral infections in pediatric populations. We discuss previously used and currently available mAbs and advancements in mAb discovery. We address the future of mAb therapy by describing novel approaches in drug production and delivery platforms in addition to alternative antibody classes. Finally, we review the challenges and limitations of mAb therapy development for newborns and children.
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Bahadır et al. (2025) conducted a review in Viral infections in pediatric populations. Human monoclonal antibodies (mAbs) was evaluated. Human monoclonal antibodies represent a promising strategy for treating and preventing viral infections in pediatric populations, though challenges in development for newborns and children remain.
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