Bacterial infection and persistent oxidative stress can impair wound healing and limit the efficacy of conventional antibacterial therapies. Here, we developed a pH- and near-infrared (NIR) light-responsive polymer hydrogel microneedle (PHMN) system by incorporating curcumin-loaded polydopamine particles (PDA@CUR) into photo-crosslinked methacrylated hyaluronic acid (HAMA) microneedles with a poly(vinyl alcohol) (PVA) backing layer. The synthesized CUR-loaded PDA nanoparticles (PDA@CUR) exhibited uniform spherical morphology, efficient CUR loading, and pH- and NIR light-responsive drug release. The fabricated PHMN/PDA@CUR patch displayed a well-defined array, sufficient mechanical strength, and efficient photothermal conversion under NIR irradiation. The patch could effectively inhibit both
No takes yet. Share an insight, caveat, or question.
Fattuhi et al. (1988) studied this question.