Key result
Regular fresh frozen plasma transfusions and close surveillance in a pregnant woman with thrombotic thrombocytopenic purpura resulted in a successful delivery and maternal recovery.
Why the study?
TTP in pregnancy is a rare, life-threatening condition sharing clinical findings with preeclampsia and HELLP syndrome, where neglected management can lead to serious maternal and fetal morbidity.
Case Report (n=1)
No
TTP in pregnancy is a rare, life-threatening condition that requires strict maternal and fetal surveillance, regular plasma transfusions, and multidisciplinary management to ensure favorable outcomes.
Supports plasma transfusion strategies in rare pregnant TTP cases; leaves open need for prospective trials before practice change.
Thrombotic thrombocytopenic purpura (TTP) is thrombotic microangiopathies, is rare medical condition that occur in pregnancy but if neglected then it will lead to serious maternal and fetal morbidity. TTP clinical findings are similar with preeclampsia, especially the HELLP (Hemolysis, Elevated Liver tests, Low Platelets) syndrome. In this case report patient is known case of TTP in pregnancy, therefore regular ANC visits and timely transfusions of fresh frozen plasma at the interval of 15 days and followed by routine CBC, BLOOD SMEAR, LFT, RFT, LDH done . TTP in pregnancy is reversible, but life-threatening medical emergency there is need of strict mother and fetal surveillance for the good result, which was done in this case, from 24 wks her first visit till the discharge of the patient as discussed in case report. Using the regular pentad solely for diagnosis of TTP will lead to underdiagnosis of many cases and should be avoided.
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Dr Neetu Kumari (2020) conducted a case report in Thrombotic thrombocytopenic purpura (TTP) in pregnancy (n=1). Fresh frozen plasma transfusions was evaluated on Maternal and fetal outcome. Regular fresh frozen plasma transfusions and close surveillance in a pregnant woman with thrombotic thrombocytopenic purpura resulted in a successful delivery and maternal recovery.
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