Biocompatible ionic liquids act as a substrate reservoir and an in situ extracting agent in biotransformations with whole cells (see scheme). In the reduction of 4-chloroacetophenone to (R)-1-(4-chlorophenyl)ethanol, high product concentration (82 g L−1) and purity (99.6 % ee) were achieved without the addition of cofactors and without damaging the biocatalyst.
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Pfruender et al. (2004) studied this question.
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