Key result
Patients with corrected atrioventricular septal defect had significantly higher mean (911 vs 703 mPa) and peak (1264 vs 1009 mPa) ascending aortic wall shear stress compared to healthy volunteers.
Why the study?
In patients after atrioventricular septal defect correction, altered geometry changes left ventricular outflow tract flow, which was hypothesized to influence ascending aortic haemodynamics.
Does repaired atrioventricular septal defect alter ascending aortic wall shear stress compared to healthy volunteers?
Cross-Sectional (n=58)
No
Does repaired atrioventricular septal defect alter ascending aortic wall shear stress compared to healthy volunteers?
Patients with corrected atrioventricular septal defect exhibit increased ascending aortic wall shear stress that correlates with increased left ventricular outflow tract velocities, suggesting altered outflow tract geometry impacts downstream aortic hemodynamics.
Repaired AVSD associates with elevated ascending aortic wall shear stress; hypothesis-generating for aortic risk, needs prospective validation.
AIM: In patients after atrioventricular septal defect correction, altered geometry leads to a changed position and subsequent flow over the left ventricular outflow tract. We hypothesised that this altered flow may influence haemodynamics in the ascending aorta. METHODS: In total, 30 patients after atrioventricular septal defect correction (age 27.6 ± 12.8 years) and 28 healthy volunteers (age 24.8 ± 13.7 years) underwent 4D flow cardiovascular magnetic resonance. Left ventricular ejection fraction and mean and peak wall shear stress calculated at ascending aortic peak systole were obtained from cardiovascular magnetic resonance. Left ventricular outflow tract data including velocity and diameter were obtained from echocardiography. RESULTS: Patients showed a higher mean (911 ± 173 versus 703 ± 154 mPa, p = 0.001) and peak ascending aortic wall shear stress (1264 ± 302 versus 1009 ± 240 mPa, p = 0.001) compared to healthy volunteers. Increased blood flow velocities over the left ventricular outflow tract (1.49 ± 0.30 m/s versus 1.22 ± 0.20 m/s, p < 0.001) correlated well with mean and peak ascending aortic wall shear stress (r = 0.67, p < 0.001 and r = 0.77, p < 0.001). CONCLUSION: After atrioventricular septal defect correction, increased wall shear stress was observed, which correlated to velocities over the left ventricular outflow tract. These findings imply that altered outflow tract geometry contributes to changed aortic haemodynamics.
No takes yet. Share an insight, caveat, or question.
Elders et al. (2019) conducted a cross-sectional in Corrected atrioventricular septal defect (n=58). Corrected atrioventricular septal defect vs. Healthy volunteers was evaluated on Mean ascending aortic wall shear stress (p=0.001). Patients with corrected atrioventricular septal defect had significantly higher mean (911 vs 703 mPa) and peak (1264 vs 1009 mPa) ascending aortic wall shear stress compared to healthy volunteers.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: