Diffuse large-cell B-cell lymphoma in a pituitary adenoma: An unusual cause of pituitary apoplexy

To the Editor: The association between hereditary hemochromatosis and thalassemia syndrome might lead to a severe iron overload [1,2], but the results are still controversial. By PCR and restriction enzyme digestion [3], we analyzed the C282Y and H63D mutations in the HFE gene in one family whose propositus carried the -thalassemia trait. The patient was a female, 38 years old, presenting weakness and arthralgia. She had 4 children and received transfusion (1 unit of red cell) during her last gestation. She did not present diabetes or cardiac disease and her hepatic enzymes were normal. Her mother and 2 sons also carried the -thalassemia trait.