Key result
In isolated rabbit hearts, D600-induced type 2 ventricular fibrillation is driven by a stationary or slowly drifting mother rotor, with local dominant frequency correlating strongly with global pseudo-ECG (r=0.97, P<0.0001).
Population
Isolated Langendorff-perfused rabbit hearts (n=22)
Design
Preclinical
Authors
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Hypothesis-generating for rotor-driven type 2 VF; leaves open human relevance and clinical translation.
p-value: p=<0.0001
Type 2 ventricular fibrillation induced by D600 in rabbit hearts is driven by a stationary or slowly drifting mother rotor, often colocalized with the papillary muscle.
Wu et al. (2004) studied Type 2 Ventricular Fibrillation (n=22). D600 infusion was evaluated on Presence of a single mother rotor and dominant frequency correlation (p=<0.0001). In isolated rabbit hearts, D600-induced type 2 ventricular fibrillation is driven by a stationary or slowly drifting mother rotor, with local dominant frequency correlating strongly with global pseudo-ECG (r=0.97, P<0.0001).
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