Pendred's Syndrome in Two Families Living in Endemic Goitre Area

other two groups.These epidemiological findings indicate a definite relationship between the nephrotic syndrome in Nigerian children and infection with P. malariae.The clinical, biochemical, and histological features are similar to those classically described in childhood, with two important differences: (1) the age at onset is much later than in Europe or America, and (2) the condition is closely associated with infection by P. malariae.We have been unable to confirm the dramatic results with antimalarial treatment reported by others.The possible mechanisms of production of " malarial nephrosis" are discussed.