The synthesis of a novel 2′,3′‐dihydrospiro(benzofuran‐2(3H),4′(1′H)isoquinoline] ring system (IV) by a nucleophilic aromatic fluoride displacement‐cyclization is described. Preparation of various derivatives of IV as well as the precursor 4‐(2‐fluorobenzyl)‐1,2,3,4‐tetrahydro‐4‐isoquinolinols is also described.
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Klein et al. (1987) studied this question.
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