Key result
FDG PET/MRI improved tumor edge detection and evaluation of invasion into adjacent structures compared to conventional Gadolinium enhanced MRI in two patients with soft tissue sarcoma.
Why the study?
Does FDG PET/MRI improve preoperative evaluation and edge detection of soft tissue sarcomas compared to conventional MRI?
Case Report (n=2)
Does FDG PET/MRI improve preoperative evaluation and edge detection of soft tissue sarcomas compared to conventional MRI?
FDG PET/MRI may provide superior edge detection and anatomical evaluation for preoperative planning in soft tissue sarcoma compared to conventional MRI.
Should not yet alter preoperative sarcoma imaging; hypothesis-generating case report requiring prospective validation.
Clinical positron emission tomography (PET)/magnetic resonance imaging (MRI) acquisition protocols may improve the evaluation of soft tissue sarcomas (STS) prior to surgical planning. We examined two patients with lower extremity STS using a Siemens Biograph mMR PET/MRI scanner and the glucose analogue 18F-fluoro-deoxyglucose (FDG). We investigated clinically relevant tumor volumes and evaluated the relations to skeletal periosteum and nerve bundles. The patient scans suggest that FDG PET/MRI improved the edge detection, and invasion of tumor tissue into important adjacent anatomical structures can be evaluated. FDG PET/MRI also provided additional information compared to conventional Gadolinium enhanced MR imaging. The findings were proven by subsequent pathological examination of the resected tumor tissue. In the future, clinical FDG PET/MRI may be an important modality for preoperative planning, including radiation therapy planning in patients with STS.
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Loft et al. (2013) conducted a case report in Soft tissue sarcoma (n=2). FDG PET/MRI vs. Conventional Gadolinium enhanced MR imaging was evaluated on Tumor edge detection and invasion into adjacent anatomical structures. FDG PET/MRI improved tumor edge detection and evaluation of invasion into adjacent structures compared to conventional Gadolinium enhanced MRI in two patients with soft tissue sarcoma.
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