July 1, 2002Carcinogenesis

Hemizygous mice for the angiotensin II type 2 receptor gene have attenuated susceptibility to azoxymethane-induced colon tumorigenesis

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Why the study?

Does Angiotensin II type 2 receptor deficiency reduce azoxymethane-induced colon tumorigenesis in mice?

Structured PICO

Does Angiotensin II type 2 receptor deficiency reduce azoxymethane-induced colon tumorigenesis in mice?

Population

Male mice with a 129/Ola and C57BL/6J genetic background or an SWR/J genetic background treated with azoxymethane (AOM) (10 mg/kg, i.p., 4 consecutive weeks) or saline vehicle

Intervention

Angiotensin II type 2 receptor gene disruption (AT2-null)

Comparator

Corresponding control wild type mice

Outcome

Colon tumor burden (prevalence, multiplicity, and size) at 23-26 weeks after initial AOM injectionsurrogate

Angiotensin II type 2 receptor deficiency attenuates azoxymethane-induced colon tumorigenesis in mice, suggesting a potential mechanism for the cancer-reducing effects of ACE inhibitors.

Discussion

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Implication

AT2 receptor role in colon tumorigenesis merits further preclinical study; leaves open any clinical implications for ACE inhibitors.

Cite This Study

Tetsuo Takagi (2002) studied this question.

synapsesocial.com/papers/6a97109fc00de92d9bfbe153 https://doi.org/10.1093/carcin/23.7.1235

View Full Paper

Ask AI

Bookmark

Hemizygous mice for the angiotensin II type 2 receptor gene have attenuated susceptibility to azoxymethane-induced colon tumorigenesis

Structured PICO

Discussion

Implication

Cite This Study

Hemizygous mice for the angiotensin II type 2 receptor gene have attenuated susceptibility to azoxymethane-induced colon tumorigenesis

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider